2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140204
    Amino-PEG9-alcohol 15332-95-3 98.0%
    Amino-PEG9-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG9-alcohol
  • HY-W248248
    tert-Butyl 9-aminononanoate 134857-22-0 ≥98.0%
    tert-Butyl 9-aminononanoate is a PROTAC linker. tert-Butyl 9-aminononanoate can be used in synthesis PROTAC sEH-degrader-1 (HY-159494).
    tert-Butyl 9-aminononanoate
  • HY-140190
    Amino-PEG2-(CH2)3COOH 1263046-77-0
    Amino-PEG2-(CH2)3COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG2-(CH2)3COOH
  • HY-119343
    Biotin-PFP ester 120550-35-8
    Biotin-PFP ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PFP ester
  • HY-124780
    HOOCCH2O-PEG4-CH2COOH 77855-75-5 ≥98.0%
    HOOCCH2O-PEG4-CH2COOH, compound 5, is a symmetric PEG linker, used for the synthesis of the first class of Homo-PROTAC.
    HOOCCH2O-PEG4-CH2COOH
  • HY-140955
    DSPE-PEG4-DBCO 2112738-14-2
    DSPE-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DSPE-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DSPE-PEG4-DBCO
  • HY-127056
    Sulfo DBCO-amine 2028284-70-8
    Sulfo DBCO-amine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. Sulfo DBCO-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    Sulfo DBCO-amine
  • HY-140822
    Bromo-PEG5-azide 1402411-90-8 99.89%
    Bromo-PEG6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromo-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Bromo-PEG5-azide
  • HY-W022232
    Boc-NH-PEG5-CH2CH2COOH 1347750-78-0
    Boc-NH-PEG5-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
    Boc-NH-PEG5-CH2CH2COOH
  • HY-130194
    Azido-PEG5-CH2CO2H 217180-81-9 98.88%
    Azido-PEG5-CH2CO2H is a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG5-CH2CO2H is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG5-CH2CO2H is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG5-CH2CO2H
  • HY-W010975
    Fmoc-Lys-OH hydrochloride 139262-23-0 99.84%
    Fmoc-Lys-OH hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Lys-OH hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-Lys-OH hydrochloride
  • HY-133406
    exo BCN-O-PNB 1380006-72-3 ≥98.0%
    exo BCN-O-PNB is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. exo BCN-O-PNB is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    exo BCN-O-PNB
  • HY-W096080
    t-Butyl acetate-PEG2-CH2COOH 883564-93-0
    t-Butyl acetate-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    t-Butyl acetate-PEG2-CH2COOH
  • HY-130342
    HO-PEG11-OH 6809-70-7 99.41%
    HO-PEG11-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    HO-PEG11-OH
  • HY-41939
    1-(2-Hydroxyethyl)piperazine 103-76-4 99.50%
    1-(2-Hydroxyethyl)piperazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    1-(2-Hydroxyethyl)piperazine
  • HY-141101
    Fmoc-PEG12-NHS ester 2227246-92-4 98.0%
    Fmoc-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-PEG12-NHS ester
  • HY-W013907
    11-Bromoundecan-1-ol 1611-56-9 99.43%
    11-Bromoundecan-1-ol is a PROTAC linker. 11-Bromoundecan-1-ol can be used to synthesize PROTACs, such as PROTAC GPX4 degrader-4 (HY-174086).
    11-Bromoundecan-1-ol
  • HY-108371
    Boc-C1-PEG2-C4-Cl 1835705-53-7 99.81%
    Boc-C1-PEG2-C4-Cl (PROTAC Linker 1) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Boc-C1-PEG2-C4-Cl
  • HY-130871A
    HS-PEG3-CH2CH2NH2 hydrochloride
    HS-PEG3-CH2CH2NH2 hydrochloride (Thiol-PEG3-amine hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    HS-PEG3-CH2CH2NH2 hydrochloride
  • HY-140492
    Biotin-PEG8-acid 2143964-62-7 98.17%
    Biotin-PEG8-acid is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG8-acid
PROTAC Linkers Isoform Comparison

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